Toh, Y.C., Ng, S., Khong, Y.M., Samper, V. and Yu, H., 2005. Yi-Chin Toh, Anju Raja, Hanry Yu, Danny van Noort, A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion, 2018, Bioengineering, 5(2): 29, Live visualisation and tracking of breast cancer cells migrating across an ECM barrier in a microfluidic 3D tumor model, Srinivasan, A., Chang, S.Y., Zhang, S., Toh, W.S.,Toh, Y.C. The assembled pumps offered a flowrate of 0.02 ~ 727.3L/min, and the smallest pump assembled with this kit was 205028mm. Dendrimer hydrazides asmultivalent transient inter cellular linkers, Biomaterials, 2008, 29 (27): 3693-3702, Ong, S.M., Zhang, C.,Toh, Y.C., Kim, S.H., Foo, H.L., Tan, C.H., van Noort, D., Park, S. and Yu, H., 2008. In this paper, we combine hPSC micropatterning and a temporallysequenced induction protocol to specify neuroepithelial (NE) cells in spatial juxtaposition to mesoendoderm cells. Development of poly (lactic-co-glycolic acid)-collagen scaffolds for tissue engineering. degrees in Chemistry and Biochemistry/Biophysics from Oregon State University (2003), and Ph.D. degree from Harvard University (2009), followed by postdoctoral training at Massachusetts Institute of Technology and Childrens Hospital Boston.
Leveraging on being smallSingapores strategy to catalyze integrative innovations, 2011,Lab on a Chip, 11: 1853-1855(Invited article), Toh, Y.C. Seep Arora, Christine Cheung, Evelyn Yim*, Yi-Chin Toh*, Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells, 2020, Biomaterials, 234, 119747. Terry Ching, Jyothsna Vasudevan, Hsih Yin Tan, Chwee Teck Lim, Javier Fernandez, Yi-Chin Toh*, Michinao Hashimoto, Highly-customizable 3D-printed peristaltic pump kit, 2021,HardwareX, e00202. Commercially available peristaltic pumps for microfluidics are usually bulky, expensive, and not customizable. He is also an elected member of the World Council of Biomechanics.
A Practical Guide to Microfluidic Perfusion Culture of Adherent Mammalian Cells. Wen, F., Chang, S.,Toh, Y.C., Teoh, S.H. Geetika Sahni, Shu-Yung Chang1, Jeremy Teo Choon Meng, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard, Kagistia Hana Utami, Puck Wee Chan, Thong Teck Tan, Umut Altunoglu, Hlya Kayserili, Mahmoud Pouladi, Bruno Reversade, Yi-Chin Toh*, A micropatterned human-specific neuroepithelial tissue for modeling gene and drug-induced neurodevelopmental defects, 2021, Advanced Science, https://doi.org/10.1002/advs.202001100.
Khong, S. Chang, V.D. It amused me to know about how the graphics and programs were squeezed in 16KB ROM cartridge and executed by an 8bit processor with just 3 internal resistors (Accumulator, X, Y) a 256 Bytes of RAM (127 Bytes of RAM for Variables & 127 Bytes shared with Television Adaptor Video memory) We demonstrated fabricating two variants of pumps with different sizes and operating flowrates using the developed kit. 2007,Materials Science and Engineering: C,27(2): 285292. At the same time, it generated tremendous respect for all the design engineers who used to work in the dark ages of electronics before HDL and EDA. Sahni, G.,Yuan, J.andToh, Y.C. Published by Elsevier Ltd. https://doi.org/10.1016/j.ohx.2021.e00202. Featured in RSCs Chemical Biology, 2007, Issue 4Featured in RSCs Chemical Biology, 2007, Issue 4. Quantitative Image-Based Cell Viability (QuantICV) Assay for Microfluidic 3D Tissue Culture Applications, Bio-mimicking shear stress environments for enhancing mesenchymal stem cell differentiation, Topography elicits distinct phenotypes and functions in human primary and stem cell derived endothelial cells, Targeting downstream subcellular YAP activity as a function of matrix stiness with Verteporn-encapsulated chitosan microsphere attenuates osteoarthritis, Fabrication of Complex 3D Fluidic Networks via Modularized Stereolithography, Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites, Self-Aligning Tetris-Like (TILE) Modular Microfluidic Platform for Mimicking Multi-Organ Interactions, Fabrication of Integrated Microfluidic Devices by Direct Ink Write (DIW) 3D Printing, Environmental specification of pluripotent stem cell derived endothelial cells towards arterial and venous subtypes, Human Pluripotent Stem Cell-derived Neural Crest Cells for Tissue Regeneration and Disease Modeling, Determination of critical shear stress for maturation of human pluripotent stem cell derived endothelial cells towards an arterial subtype, A liver-immune coculture array for predicting systemic drug-induced skin sensitization, A 3D Microfluidic Model to Recapitulate Cancer Cell Migration and Invasion, Substrate stiffness modulates the multipotency of neural crest derived human ectomesenchymal stem cells via CD44 mediated PDGFR signaling, A 3D Printed Microfluidic Perfusion Device for Multicellular Spheroid Cultures, A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells, Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity, Functionally enhanced human stem cell derived hepatocytes in galactosylated cellulosic sponges for hepatotoxicity testing, Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates, Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules, A method for human teratogen detection by geometrically confined cell differentiation and migration, Modulation of integrin and E-cadherin-mediated adhesions to spatially control heterogeneity in human pluripotent stem cell differentiation, A scalable method for aligning 3D micro-tissues in microfluidic chips, Scalable cell alignment on optical media substrates, Mechanical compaction directly modulates the dynamics of bile canaliculi formation, Leveraging on being smallSingapores strategy to catalyze integrative innovations, Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction, Advancing Stem Cell Research with microtechnologies: opportunities and challenges, A microfluidic 3D hepatocyte chip for drug toxicity testing, The controlled presentation of TGF-b1 to hepatocytes in a 3D microfludic cell culture system, Microfabricated silicon nitride membranes for hepatocyte sandwich culture, Dendrimer hydrazides asmultivalent transient inter cellular linkers, A gel-free 3D microfluidic cell culture system, Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection, Development of dual-compartment perfusionbioreactor for serial coculture of hepatocytes and stellate cells in poly (lactic-co-glycolic acid)-collagen scaffolds, A Practical Guide to Microfluidic Perfusion Culture of Adherent Mammalian Cells, A novel 3D mammalian cell perfusion-culture system in microfluidic channels. She obtained her B.Eng in Chemical Engineering and Ph.D in Bioengineering from the National University of Singapore in 2001 and 2008 respectively. Yi-Chin Toh is a Future Fellow and Associate Professor at the Queensland University of Technology. Different endothelial cell subtypes often exhibit similar morphological response to topographical cues, however, they can demonstrate different phenotypic and functional responses. The controlled presentation of TGF-b1 to hepatocytes in a 3D microfludic cell culture system, 2009,Biomaterials, 2009, 30: 3847-3853, Zhang, S., Xia, L., Kang, C.H., Xiao, G., Ong, S.M.,Toh, Y.C., Leo, H.L., van Noort, D., Kan, S.H., Tang, H.H. Rapid customization of the instrument would benefit users. 2015,Biomaterials,70, pp.115-125. He served as a visiting scholar at multiple institutions, including Polish Academy of Science (Poland), University of Sao Paulo (Brazil), National Tsinghua University (Taiwan), the University of Tokyo (Japan), and EXPEC Advanced Research Center at Saudi Aramco (Saudi Arabia). 2005,Biomaterials,26(19): 41494160. 2015,Scientific Reports. Using a modular design, the kit is easily customizable, easy to replace, and has exceptional forward compatibility. I had a lot of fun practising Multisim.
I am glad to share that I have completed a summer internship Qiskit where I learn various topics in Quantum Computers. To demonstrate the forward compatibility, we developed a flowrate calibration tool that was readily interfaced with the developed pump system. By continuing you agree to the use of cookies. Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection, 2008,Analyst, 133: 326-330, Wen, F., Chang, S.,Toh, Y.C., Arooz, T., Zhuo, L., Teoh, S.H. Javiers research at SUTD is focused on the broadstudy, development, and application of biological materials in science and technology. Hsih Yin Tan and Yi-Chin Toh*, What can microfluidics do for microbiome research?
She worked on the synthesizing and characterizing of Chitosan/Diopside scaffolds and their applications as Bone Tissue Engineering substrates. https://lnkd.in/d47jYS3. While miniature pumps are commercially available, they require proprietary and expensive control systems. Toh, Y.C., Xing, J. and Yu, H., 2015. 2007,Lab on a Chip, 2007, 7: 681-694. and Yu, H., 2015. Shrilk is referred, for example, to as one of the materials that will change the future of manufacturing (Scientific American), a Supermaterial (National Geographic), and has been chosen (with graphene) one of the five material that could change the word (The Guardian).
Seep Arora, Jing Ying Adele Lam, Christine Cheung, Evelyn KF Yim, Yi-Chin Toh*, Microtechnologies for Experimental Stem Cell Biology, Highly-customizable 3D-printed peristaltic pump kit, A micropatterned human-specific neuroepithelial tissue for modeling gene and drug-induced neurodevelopmental defects, Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow, Acrylated Epoxidized Soybean Oil / Hydroxyapatite-Based Nanocomposite Scaffolds Prepared by Additive Manufacturing for Bone Tissue Engineering.
Tasnim, F., Phan, D., Toh, Y.C. The journey of how circuits are transferred on silicon wafers.
It took me approx 2 hrs to complete, but finally, I found the answer. Dibakar Mondal, Akshaya Srinivasan, Patricia Comeau, Yi-Chin Toh*, Thomas L Willett, Acrylated Epoxidized Soybean Oil / Hydroxyapatite-Based Nanocomposite Scaffolds Prepared by Additive Manufacturing for Bone Tissue Engineering, 2021, Materials Science & Engineering C, 118:111400. Currently, she is a postdoctoral fellow of Institute of Health Innovation and Technology in Prof C. T. Lim's group at the National University of Singapore. However, quantification of cell viability in dense 3D tissue constructs is not straightforward. After his Ph.D, Javier moved to MIT, where he developed the Micro-Masonry, a technology to assemble artificial organs and recognized as breakthrough in tissue engineering (CNET). | How does your Smartphone store data? Spatially organizedin vitromodels instruct asymmetric stem cell differentiation, 2011,Integrative Biology, 3: 1179-1187, Toh, Y.C., Kang, T.G., van Noort, D., Burkholder, B. and Zhang, J.B., 2011.